![]() ![]() (using an early Macintosh Apple computer) developed the ability to produce quantitative data, such as peripapillary nerve fiber layer thickness. During the same period, Michael Hee, M.D., Ph.D. This led to the development of the first OCT atlas in 1996, which would serve as a framework for OCT image interpretation. Starting in 1993, with support from the National Institutes of Health, OCT imaging using a prototype device was performed on over 5000 out-patients at the New England Eye Center at Tufts Medical Center. The clinical utility of these images, however, remained obscure. Just two years after Huang’s seminal paper, a new prototype produced the very first images of an in-vivo human retina outside of a laboratory. The application of fiber optic and intersatellite communication technology shrunk lab-based mega-OCTs into an instrument that was only 19 inches wide and 100x faster. (D) Cystoid macular edema.Ī subsequent collaboration with Eric Swanson of MIT Lincoln Laboratories led to dramatic advances in early OCT technology. published the very first retinal OCT images of an ex-vivo human eye, pioneering the conversion of several individual A-scans into a single B-scan image. This proved to be transformative, and in 1991, Huang et al. Faced with limited success, however, the group decided to test its potential in retinal imaging. and Carmen Puliafito, M.D., trialed this concept by using low-coherence interferometry for the measurement of corneal thickness. James Fujimoto at the Massachusetts Institute of Technology (MIT) and assisted by ophthalmologists Joel Schuman, M.D., David Huang, M.D. ![]() In the late 1980s, a team of researchers, led by Dr. The eye, as a clear, low interference media, became a natural choice for testing this theory. Duguay and Ippen built the foundation for a concept called optical reflectivity, the idea that light interference could be used to produce a non-invasive optical ‘biopsy’. The early ‘protozoal’ period started in the early to mid-1970s at Bell Laboratories (AT&T), where Drs. The history of optical coherence tomography (OCT) reads like a fossil record, with a primordial decades-long process followed by a more recent, explosive evolution in technology. Prototype OCT machine used at the New England Eye Center in 1993. ![]()
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